Table 2. Association of Esophagitis with the top 16 MicroRNA SNPs.

SNP	Gene	Site	Chr	Allelic change	Model*	OR (95% CI)#	p
rs10274	RPS6KB2	binding	11	G>A	rec	0.19 (0.07–0.51)	0.001^
rs1061280	SMO	binding	7	A>G	dom	0.19 (0.07–0.53)	0.001^
rs1061285	SMO	binding	7	C>A	dom	0.19 (0.07–0.53)	0.001^
rs3124591	NOTCH1	binding	9	A>G	add	0.39(0.20–0.75)	0.005
rs1133043	GPR30	binding	7	C>G	rec	0.16(0.04–0.64)	0.01
rs16950113	SMAD7	binding	18	A>G	dom	0.23(0.07–0.75)	0.015
rs713065	FZD4	binding	11	G>A	add	2.36(1.14–4.89)	0.02
rs2740351	GEMIN4	processing	17	A>G	add	2.15(1.12–4.12)	0.022
rs7813	GEMIN4	processing	17	A>G	add	2.15(1.12–4.12)	0.022
rs2075993	E2F2	binding	1	A>G	rec	0.32(0.11–0.90)	0.03
rs7588	PLK1	binding	16	G>A	dom	0.40(0.17–0.92)	0.031
rs573010	RNASEN	processing	5	C>A	rec	0.14(0.02–0.84)	0.031
rs1052133	OGG1	binding	3	C>G	add	2.34(1.07–5.10)	0.033
rs4690150	FGF5	binding	4	C>G	dom	2.53(1.06–6.01)	0.036
rs2248718	ATP6V1C1	binding	8	G>A	add	0.49(0.25–0.98)	0.043
rs4246215	FEN1	binding	11	C>A	dom	2.51(1.03–6.10)	0.043

* add, additive

dom, dominant

rec, recessive

^# Adjusted for age, sex, clinical stage, performance status, smoking status, radiation therapy type, radiation treatment type and dose and lung function

^ p value <0.05 and q value< 0.1.