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. 2016 Mar;39:21–33. doi: 10.1016/j.dnarep.2015.11.004

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© 2015 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 5 — The spectrum of TP53 mutations induced by 3-NBA in Xpa-WT and Xpa-Null HUFs compared with mutations found in human tumours. Shown are (A) the number of mutations at each codon (within exons 4–9) in the TP53 gene induced by 3-NBA in HUFs compared with the frequency of mutation at each codon in (B) lung cancer of smokers (exclusions: radon, asbestos, mustard gas, and coal [65], [66], (C) lung cancer of non- and passive-smokers (exclusions: radon, asbestos, mustard gas, and coal [65], [66] and (D) cancer overall. Reference for the codon distribution of TP53 mutations in human cancer: IARC TP53 Mutation Database, R17 (November 2013). Mutation hotspots are indicated in grey.