Table 2.
Adjusted associations for mammographic density and alcohol intake, EDMD, 2001–2006
| Model 1: Age Adjusted | Model 2: Age And BMI Adjusted | Model 3: Fully Adjusted | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Percent Density | Dense Area | Percent Density | Dense Area | Percent Density | Dense Area | |||||||
| β | 95% CI | β | 95% CI | β | 95% CI | β | 95% CI | β | 95% CI | β | 95% CI | |
| Alcohol intake between age 20–29 years (servings/week)a | ||||||||||||
| 0 | Ref | -- | Ref | -- | Ref | -- | Ref | -- | Ref | -- | Ref | -- |
| <3 | 1.18 | −2.60, 4.95 | 1.50 | −3.10, 6.10 | −0.67 | −3.94, 2.59 | 0.85 | −3.66, 5.37 | −1.33 | −4.60, 1.93 | 0.26 | −4.29, 4.83 |
| 3–7 | 1.71 | −2.10, 5.52 | 1.91 | −2.70, 6.52 | −0.24 | −3.71, 3.23 | 1.20 | −3.36, 5.77 | −1.69 | −5.19, 1.82 | 0.52 | −4.20, 5.23 |
| >7 | −4.03 | −8.12, 0.06 | −3.01 | −7.38, 1.36 | −3.96 | −7.60, −0.33 | −2.99 | −7.31, 1.32 | −5.11 | −8.71, −1.52 | −4.00 | −8.25, 0.24 |
| P for trend | 0.16 | 0.39 | 0.07 | 0.33 | <0.01 | 0.15 | ||||||
| Current alcohol intake (servings/week)b | ||||||||||||
| 0 | Ref | -- | Ref | -- | Ref | -- | Ref | -- | Ref | -- | Ref | -- |
| <3 | 3.75 | 0.30, 7.19 | 1.12 | −2.82, 5.06 | −0.57 | −3.38, 2.24 | 0.07 | −3.87, 4.02 | −0.75 | −3.53, 2.03 | 0.30 | −3.65, 4.25 |
| 3–7 | 3.86 | 0.31, 7.42 | 5.37 | 0.77, 9.97 | −2.13 | −5.34, 1.09 | 4.12 | −0.65, 8.88 | −2.00 | −5.20, 1.20 | 3.79 | −0.99, 8.58 |
| >7 | −0.18 | −4.72, 4.37 | 1.61 | −4.32, 7.53 | −3.64 | −7.53, 0.24 | 1.29 | −4.69, 7.27 | −3.13 | −7.03, 0.77 | 0.14 | −5.79, 6.06 |
| P for trend | 0.44 | 0.14 | 0.04 | 0.26 | 0.08 | 0.44 | ||||||
Abbreviation: EDMD, Early Determinants of Mammographic Density; CI, confidence interval;
Alcohol intake age 20–29 years when modeling for Percent Density are as follows: Model 1 is adjusted for age at mammogram (years); Model 2 includes model 1 adjustments and BMI in 20s (continuous); and Model 3 includes model 2 adjustments, geographic site, current smoking status (never (referent), former, current), parity (nulliparous, parous), and age at first birth modeled at the mean. Alcohol intake age 20–29 years when modeling for Dense Area are as follows Model 1 is adjusted for age at mammogram (years); Model 2 includes model 1 adjustments and BMI in 20s (continuous); and Model 3 includes model 2 adjustments, geographic site, hormonal birth control use (never, ever), parity (nulliparous, parous), and age at first birth modeled at the mean.
Current alcohol intake when modeling for Percent Density are as follows: Model 1 is adjusted for age at mammogram (years); Model 2 includes model 1 adjustments and current BMI; Model 3 includes model 2 adjustments, geographic site, and race. Current alcohol intake when modeling for Dense Area models are as follows: Model 1 is adjusted for age at mammogram (years); Model 2 includes model 1 adjustments and current BMI (continuous); Model 3 includes model 2 adjustments, geographic site, and menopausal status (premenopausal, peri/post-menopausal).