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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: Adv Drug Deliv Rev. 2015 Oct 9;99(Pt A):28–51. doi: 10.1016/j.addr.2015.09.012

Figure 3.

Figure 3

Novel alternative approaches to PEGylation for increasing the systemic circulation time of NPs. (A) PS NPs were attached to red blood cells via reversible electrostatic and hydrophobic interactions, prolonging systemic circulation time and increasing accumulation in the lungs. Adapted with permission from [115]. (B) Attaching minimal “self” peptides designed to mimic the “marker of self”, CD47, to the surface of PS NPs led to increased circulation time and enhanced tumor accumulation compared to control NPs. Adapted with permission from [116].