Table 1.
Identified causative variants in 14 samples (4 samples remain unsolved).
| Sample ID | Sample Status | Gene | Transcript | Nucleotide change | Protein Change |
|---|---|---|---|---|---|
| 1 | Positive control | TMC1 | NM_138691.2 | c.[1589_1590delCT];[1589_1590delCT] | p.[Ser530*];[Ser530*] |
| 2 | Positive control | MYO15A | NM_016239.3 | c.[4652C>A];[4652C>A] | p.[Ala1551Asp];[Ala1551Asp] |
| 3 | Positive control | CIB2 | NM_006383.3 | c.[330T>A];[330T>A] | p.[Tyr110*];[Tyr110*] |
| 4 | Positive control | TMC1 | NM_138691.2 | c.[1718T>A];[2130-1delG] | p.[Ile573Asn];splice acceptor |
| 5 | Positive control | GJB2 | NM_004004.5 | c.[35delG];[35delG] | p.[Gly12Valfs*2];.[Gly12Valfs*2] |
| 6 | Positive control | GJB2 | NM_004004.5 | c.[35delG];[−23+1G>A] | p.[Gly12Valfs*2];splice acceptor |
| 7 | Solved | USH2A | NM_206933.2 | c. [2299delG];[12067-2A>G] | p.[Glu767Serfs*21];splice acceptor |
| 8 | Solved | GJB2 | NM_004004.5 | c.[427C>T];[269T>C] | p.[Arg143Try];[Leu90Pro] |
| 9 | Solved | MITF | NM_000248.3 | c.[1195G>A];[=] | p.[Gly399Arg];[=] |
| 10 | Solved | GJB2 | NM_004004.5 | c.[35delG];[139G>T] | p.[Gly12Valfs*2];[Glu47*] |