Table 1.

A list of reported representative substrates of FBXW sub-family proteins in cell cycle regulation.

Substrates	F-box	Functions	References
Emi1	β-TRCP	Inhibitor of APC/C, Cell cycle	(Guardavaccaro, Kudo, 2003, Margottin-Goguet, Hsu, 2003)
Cdc25A	β-TRCP	Protein phosphatase, Cell cycle	(Busino, Donzelli, 2003, Jin, Shirogane, 2003)
Cdc25B	β-TRCP	Protein phosphatase, Cell cycle	(Kanemori, Uto, 2005, Uchida, Watanabe, 2011)
Wee1A	β-TRCP	Protein kinase, Cell cycle	(Watanabe, Arai, 2004)
Cyclin D1	β-TRCP	Cyclin, Cell cycle	(Seki, Coppinger, 2008, Wei, Yang, 2008)
BTG	β-TRCP	Transcription factor, Cell cycle	(Sasajima, Nakagawa, 2012)
Plk4	β-TRCP	Protein kinase, Centrosome duplication	(Cunha-Ferreira, Rodrigues-Martins, 2009, Guderian, Westendorf, 2010)
CEP68	β-TRCP	Centrosome separation	(Pagan, Marzio, 2015)
Bora	β-TRCP	Aurora A kinase activator, Cell cycle	(Seki, Coppinger, 2008)
Securin	β-TRCP	Regulatory protein, Cell cycle	(Limon-Mortes, Mora-Santos, 2008)
REST	β-TRCP	Spindle assembly checkpoint	(Guardavaccaro, Frescas, 2008)
Claspin	β-TRCP	DNA replication checkpoint	(Peschiaroli, Dorrello, 2006)
hGCMa	FBXW2	Transcription factor, Cell cycle	(Yang, Yu, 2005) (Zhuang, Li, 2014)
COP9	FBXW4	Cell growth, Cell cycle	(Lockwood, Chandel, 2013)
Eps8	FBXW5	Mitosis, Cell cycle	(Werner, Disanza, 2013)
DLC1	FBXW5	Tumor suppressor, Cell growth	(Jiang, Li, 2015, Kim, Jackson, 2013)
HsSAS-6	FBXW5	Centrosome duplication, Cell cycle	(Hu, Zacharek, 2008, Pagan and Pagano, 2011, Puklowski, Homsi, 2011)
Cyclin E	FBXW7	Protein kinase, Cell cycle	(Perciavalle and Opferman, 2013, Siu, Rosner, 2012, Spruck, Won, 1999)
Aurora A/B	FBXW7	Mitosis, Cell cycle	(Kwon, Kim, 2012, Slattery, Moore, 2008, Teng, Hsieh, 2012)
Cyclin D1	FBXW8	Cell growth, Cell cycle	(Okabe, Lee, 2006)
HPK1	FBXW8	Cell growth, Cell cycle	(Wang, Chen, 2014a)