Table 3.
A list of reported representative substrates of FBXO sub-family prorteins in cell cycle.
| Substrates | F-box | Functions | References |
|---|---|---|---|
| Cyclin B | FBXO1 | Cyclin, Cell cycle | (Fung, Siu, 2002, Kong, Barnes, 2000) |
| CP110 | FBXO1 | Centrosome duplication, Cell cycle | (D'Angiolella, Donato, 2010) |
| RRM2 | FBXO1 | DNA repair, Cell cycle | (D'Angiolella, Donato, 2012) |
| NUSAP1 | FBXO1 | Microtubule, Cell cycle | (Emanuele, Elia, 2011) |
| Smurf1 | FBXO3 | Cell cycle | (Li, Xie, 2015) |
| Cyclin D1 | FBXO4 | Cyclin, Cell cycle | (Barbash, Zamfirova, 2008, Lin, Barbash, 2006, Santra, Wajapeyee, 2009) |
| P53 | FBXO5, FBXO11 | Tumor suppressor, Cell cycle | (Lehman, Verschuren, 2006) |
| Chk1 | FBXO6 | Replication checkpoint, Cell cycle | (Zhang, Brognard, 2009) |
| Cyclin D/Cdk6/p27 | FBXO7 | Cyclin, Cell cycle | (Laman, Funes, 2005) |
| HURP | FBXO7 | Oncogene, Cell cycle | (Hsu, Lee, 2004) |
| Cdt2 | FBXO11 | Cell cycle | (Abbas, Keaton, 2013a) |
| Bcl6 | FBXO11 | Cell cycle | (Duan, Cermak, 2012) |
| EID1 | FBXO21 | Cell cycle | (Zhang, Li, 2015) |
| KDM4A | FBXO22 | Cell cycle | (Tan, Lim, 2011) |
| Cdt1 | FBXO11, FBXO31 | Cell cycle | (Johansson, Jeffery, 2014) |
| MDM2 | FBXO31 | Cell cycle | (Malonia, Dutta, 2015) |
| BRCA1 | FBXO44 | DNA repair, Cell cycle | (Lu, Li, 2012) |
| Par-4 | FBXO45 | Apoptosis, Cell cycle | (Wang and Wei, 2014) |
| P73 | FBXO45 | Tumor suppressor, Cell cycle | (Peschiaroli, Scialpi, 2009) |