Figure 2. Infection outcomes and protective immunity in mice infected with IAV.
(A, B) Weights of mice (proportion of starting weight) of mice inoculated with 200 PFU of IAV WT and mutant strains with altered dinucleotide compositions. Deaths of individual mice are shown underneath the x-axis using the same colour coding. (C) Weight loss of mice infected with different inoculum doses (20–200 PFU) of the CpG-high IAV mutant (D) weight loss in the mice previously infected with CpG-high IAV (in Figure 2C) with a 200 PFU WT challenge dose at day 21 after the original inoculation. In all graphs, error bars show SEMs of 4–6 mice per group.