Figure 7. Predicted and observed effects of HYP and DEP mutations on dwell times.

(A) Predicted effects of changes in membrane potential. (B ) Predicted effects of changes in input resistance. (C) Dwell times in F, R, and P for cohorts of HYP mutants, DEP mutants, and wild type animals. Stars indicate significant change in dwell time (p<0.05 without ($\star$) or with ($\star \star$) correction for multiple comparisons; Table 6). In A-C wild type dwell times are indicated by gray bars. Horizontal lines indicate the estimated range of ${\displaystyle d_0}$ , the dwell time in the uncoupled state. In the ΔV model, $h$ terms were made more negative to model HYP mutants and more positive to model DEP mutants by subtracting or adding a constant ${\displaystyle \mathrm{\Delta }h}$ = 0.6; qualitatively similar results were obtained for 0 < $∆h$ ≤ 0.8. In the Δr model, ${\displaystyle h}$ and $w$ terms were scaled by (1 + f) to model HYP mutants and by (1 - f) to model DEP mutants, with f = 0.6; qualitatively similar results were obtained for 0 < f ≤ 1. Strains, HYP A: DA572 eat-4(ad572); HYP B: MT6308 eat-4(ky5); HYP C: KP4 glr-1(n2461); DEP A: VM1136 lin-15(n765); akIs9 [lin-15(+), Pglr-1::GLR-1(A/T)]; DEP B: VM188 lin-15(n765); akEx52[lin-15(+), Pnmr-1::GLR-1(A/T)].