Table 6. Effects of mutations on model parameters.
Significance was determined using the likelihood ratio test as described in Table 4. The sign of the change (Δ) caused by the mutation is shown as “+” if the value moved away from 0, “–” if the value moved towards 0. All p-values are shown without correction for multiple comparisons. Blue denotes significance at p<0.05. Red denotes significance at p<0.05 after Bonferroni correction for 27 comparisons.
HYP | DEP | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
HYP A: eat-4(ad572) | HYP B: eat-4(ky5) | HYP C: glr-1(n2461) | DEP A: glr-1::glr-1(A/T) | DEP B: nmr-1::glr-1(A/T) | ||||||||||||||||
Control | Mutant | p < | Control | Mutant | ∆ | p< | Control | Mutant | ∆ | p< | Control | Mutant | ∆ | p< | Control | Mutant | ∆ | p< | ||
(s) | 4.771 | 9.564 | + | 10-87 | 4.956 | 8.643 | + | 10-64 | 5.181 | 7.871 | + | 10-33 | 4.771 | 0.940 | – | 10-99 | 5.181 | 0.742 | – | 10-99 |
(s) | 2.043 | 2.821 | + | 10-7 | 1.910 | 2.769 | + | 10-12 | 2.018 | 3.004 | + | 10-16 | 2.045 | 0.875 | – | 10-99 | 2.018 | 0.709 | – | 10-9 9 |
(s) | 0.481 | 1.040 | + | 0.005 | 0.529 | 0.844 | + | 10-43 | 0.459 | 0.727 | + | 10-39 | 0.482 | 0.328 | – | 10-49 | 0.460 | 0.235 | – | 10-99 |
(s) | 0.247 | 0.382 | + | 10-5 | 0.238 | 0.290 | + | 0.005 | 0.221 | 0.164 | – | 10-5 | 0.247 | 0.097 | – | 10-93 | 0.221 | 0.079 | – | 10-99 |
(s) | 0.428 | 0.982 | + | 10-99 | 0.466 | 0.793 | + | 10-52 | 0.409 | 0.677 | + | 10-43 | 0.428 | 0.286 | – | 10-61 | 0.409 | 0.204 | – | 10-99 |
0.729 | 0.839 | + | 10-27 | 0.734 | 0.832 | + | 10-26 | 0.755 | 0.785 | + | 0.003 | 0.728 | 0.410 | – | 10-99 | 0.755 | 0.407 | – | 10-99 | |
0.177 | 0.062 | – | 10-37 | 0.167 | 0.079 | – | 10-29 | 0.161 | 0.135 | – | 10-4 | 0.177 | 0.389 | + | 10-99 | 0.161 | 0.404 | + | 10-99 | |
0.073 | 0.090 | + | 10-5 | 0.077 | 0.081 | + | 0.3 | 0.067 | 0.073 | + | 0.03 | 0.073 | 0.164 | + | 10-99 | 0.067 | 0.151 | + | 10-99 | |
0.022 | 0.009 | – | 10-13 | 0.021 | 0.008 | – | 10-25 | 0.018 | 0.007 | – | 10-27 | 0.022 | 0.037 | + | 10-21 | 0.018 | 0.037 | + | 10-41 |