Fig. 2.

Endocan expression in pituitary adenoma, normal pituitary and primary hepatic carcinoma. Endocan was overexpressed in tumor cells and a few vascular endothelial cells in Grade 4 pituitary adenomas. Tumor cells surrounded the blood vessel intensely, with endocan characteristically distributed in the cytoplasm and polarized towards the blood vessel lumen (a). Endocan was weakly expressed in endocrine cells and a few vascular endothelial cells in the normal pituitary gland (b). In primary hepatic carcinoma, endocan was over-expressed in vascular endothelial cells within the cancer nests and adjacent tumor cells (c). Magnification: A, ×400; B, ×100; C, ×400