Table 2.
Main neurotrophic factors used in peripheral nerve repair.
Growth factor | Main target | Reference |
---|---|---|
NGF | Sensory neurons and small axons | 63, 64, 65 |
BDNF | Sensory neurons and large axons | 66, 67, 68 |
NT-3 | Sensory and motor neurons | 69 |
NT-4/5 | Motor neurons | 62 |
GDNF | Motor neurons | 70 |
CNTF | Sciatic nerve | 71 |
IGF | Inflammatory (anti-inflammatory) cells; sensory and motor neurons | 72, 73, 74, 75 |
VEGF | Vascular endothelial cells | 76, 77, 78 |