Table 1.
Shared properties of cells capable of cytokine-induced cytokine production.
Features of cytokine production | |||
---|---|---|---|
Cytokine produced | IFNγ | IL-13/IL-5/(IL-4) | IL-17/IL-22 |
T helper cells | Th1 | Th2 | Th17 |
Innate lymphoid cells | cNK | nuocytes | ILC22 |
tNK | natural helpers (NH) | ILC17 | |
innate helper type2 | LTi | ||
Innate-like T cells | IL-18-responsive NKT subset | IL-25 responsive NKT subset | IL-23 responsive NKT subset |
γδ T cell subset | γδ T cell subset | ||
Innate CD8 T cells | |||
Receptors | IL-18R | T1ST2 (IL-33R) | IL-1R1 |
IL-12R | IL-17RB (IL-25R) | IL-23R | |
IL-2R | |||
IL-7R | |||
TSLPR | |||
Stimulating cytokines | IL-18 | IL-33/IL-25 | IL-1β |
IL-12 | IL-2/IL-7/TSLP | IL-23 | |
Transcription factors | T-bet (Th1, cNK, NKT subset) | GATA3 (Th2 and ILC2 cells?) | RORγt |
Eomes (cNK and innate CD8 T) | RORα (ILC2 cells) | AhR |