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. 2015 Dec 28;30(4):1623–1633. doi: 10.1096/fj.15-281741

Figure 5.

Figure 5.

High-resolution respirometry in WT and mKO TRI muscle. A) Respiratory flux normalized to muscle weight in the presence of MOct (leak respiration in the absence of adenylates), ADP (D), cytochrome c (C; mitochondrial integrity), glutamate [G; complex I (CI) capacity], succinate [S; complex I + complex II (CII) capacity], carbonyl cyanide m-chloro phenyl hydrazone (U; maximal respiration), rotenone (Rot; complex II capacity), and Ama [residual oxygen consumption (Rox)]. B) Respiratory flux normalized to muscle weight in the presence of PM followed by the same titrations in (A). C) Fatty acid oxidation (FAO) and pyruvate oxidation (PM)-coupling control factor, calculated as (P − L)/P, respectively. D) Complex II-linked flux control ratio, calculated as complex II/(complex I + complex II). Data are reported as means ± sem (n = 6 per genotype). *P < 0.05 PM vs. FAO.