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. 2015 Dec 20;30(4):1670–1682. doi: 10.1096/fj.15-279802

Figure 1.

Figure 1.

Mϕs secrete a factor causing a change in EC monolayer permeability. A) Normalized resistance of HREC monolayers treated with a 1:5 dilution of CM. A significant decrease is seen in the resistance of cells treated with U937 Mϕ CM compared to HRECs treated with Ctrl, or the CM from U937 Monos. *P = 0.007, significantly less than cells in Ctrl. B) Schematic representation of the method used for the preparation of U937 Mono and Mϕ CM. Mass Spec., mass spectrometry; Mol. Wt., molecular mass. C) Normalized resistance of HREC monolayers treated with a 1:5 dilution of fractionated U937 Mϕ CM: 3–10, 10–30, 30–100, and 100–300 kDa. Data are the means ± sd. *P = 0.004, significantly less than cells in Ctrl.