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. 2015 Dec 15;213(8):1330–1339. doi: 10.1093/infdis/jiv584

Figure 3.

Figure 3.

Thermal shift assay to measure MprA conformational change in response to DU011 and prototypic ligands. A, Comparison of the thermal profiles of MprA with and without DU011, DU003, salicylate, 2,4-dinitrophenol (DNP), or nalidixic acid. B, Thermal shift of MprA with increasing concentrations of DU011. The melt curve is represented as normalized data calculated as follows: d(fluorescence)/d(temperature).