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. 2015 Dec 15;213(8):1330–1339. doi: 10.1093/infdis/jiv584

Figure 4.

Figure 4.

Comparative structural analysis capsule inhibitors DU003, DU011, and prototypic MprA ligands. A, Structures for nalidixic acid (Nal), salicylate (Sal), 2,4-dinitrophenol (DNP), DU003, and DU011, with the proposed recurrent bioisosteric functional groups highlighted in blue (carboxylic acid and nitro), green (phenol and aminothiophene/amide nitrogen), and purple (phenyl and thiophene rings). B, Graphic structure overlay results from morphological similarity analysis on Nal, Sal, DNP, DU003, and DU011. C, Morphologic similarity values between Nal, Sal, DNP, DU003, and DU011. Darker green indicates higher similarity.