Figure 6.

Comparison of the efficacy of T-705 and equine rabies immunoglobulin (ERIG) as postexposure treatments. Mice were intramuscularly inoculated with 1088 and orally administered T-705 (300 mg/kg/day) daily for 7 days (days 0–6) beginning 1 hour (0 days), 1 day, or 2 days after inoculation, or were intramuscularly injected with 40 IU/kg of ERIG at the virus inoculation site at 1 hour (on 0 day), 1 day, or 2 days after inoculation. Inoculated mice without any treatments were used as controls. Mice were monitored for 28 days. “Sick” indicates that mice showed significant body weight loss or neurological signs. Surviving sick mice had begun to gain body weight but with sequelae, such as limb paralysis. For the survival curves, log-rank tests were performed, and the P values are indicated in the figure. A P value of <.0056 (after Bonferroni correction) was considered significant.