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. 2016 Feb 9;213(8):1289–1298. doi: 10.1093/infdis/jiw054

Figure 2.

Figure 2.

Granulocyte-macrophage colony-stimulating factor receptor β chain (GM-CSFRβ) signaling and neutrophil and monocyte recruitment during respiratory fungal infection. A–C, Wild-type (WT) mice were infected with 3 × 107 CEA10 conidia, and recruitment of neutrophils (A), inflammatory monocytes (B), and monocyte-derived dendritic cells (DCs) (C) in lungs was measured with flow cytometry at the indicated time points; representative data from 3 independent experiments are shown (WT: n = 10, GM-CSFRβ−/−: n = 7). D–I, Graphs show mean (standard error of the mean) lung cytokine and chemokine levels 24 hours after infection in C57BL/6 WT or GM-CSFRβ−/− mice infected with 3 × 107 CEA10 conidia; representative data from 2 independent experiments are shown (WT: n = 10; GM-CSFRβ−/−: n = 13). *P < .05; †P < .01; ‡P < .001; §P < .0001. Abbreviations: MCP-5, monocyte chemotactic protein 5; NS, not significant; TNF, tumor necrosis factor.