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. 2015 Sep 18;18(4):497–506. doi: 10.1093/neuonc/nov170

Fig. 1.

Fig. 1.

Extracellular vesicle (EV) concentration differentially affects cytokine output and proliferation of (naïve) PHA-stimulated peripheral blood mononuclear cells (PBMCs). (A) ELISA IL-2 measurements (24 h) from PHA-stimulated Jurkats + various EV concentrations (asterisks = t test vs PHA stimulation). (B) IFNγ ELISA (72 h) from PBMCs + PHA alone or +100 or 2000 µg/mL EVs (t test vs No Tx control). (C) Average PBMC proliferation (72 h) with PHA alone or +100 or 2000 µg/mL EVs. Values displayed as fold change versus No Tx control. No Tx = untreated control cells. *P < .05, **P < .01, ***P < .001.