Fig. 3.

Kaplan–Meier plots for all 288 patients showing progression-free survival (PFS) and overall survival (OS) according to the combined IDH1 and tumor edema status. Mutant (mut) IDH1 tumors with no edema predicted better survival (PFS, P = .003; OS, P = .004, log-rank) (A and D). In patients with mutated IDH1, the absence of edema was also a significant prognostic factor for PFS (P = .024, log-rank) and OS (P = .032, log-rank) (B and E). However, the edema was not associated with survival in patients with wild-type (wt) IDH1 tumors (PFS, P = .242; OS, P = .191, log-rank) (C and F).