Fig. 1.

Pharmacodynamic effects of PLX3397 in recurrent GB. (A) Automated quantification of IHC changes in IBA1 staining in paired archival and surgical specimens from study subjects on PLX3397 and nonstudy control subjects treated with RT + TMZ. (B) Representative IBA1 IHC staining for control (post RT + TMZ) and study subject PLX-102 (RT + TMZ followed by PLX3397). The size bar is 30 μm. (C) Group comparison of IBA1 vs the change seen in individual patients (second panel, delta) as assessed by automated and manual review. Automated quantification of IHC for pERK and MIB1.