Table 4.

Adjusted Associations of PTH with Prospective WMH Volume Change and Risk of Incident Infarcts over follow-up from ARIC visit 3 (1993–1994) to ARIC Brain MRI visit (2004–2006).

	Per 1 unit increase in log(PTH)	PTH≥65 vs <65
Over all No.	1703	204 (12.0%)
WMH volume change, cm3	β coef (95% CI)	β coef (95% CI)
Model 1	0.88 (−1.43, 3.19)	1.48 (−0.56, 3.53)
Model 2	1.09 (−1.27, 3.44)	1.39 (−0.73, 3.51)
Model 3	0.77 (−1.55, 3.09)	0.92 (−1.21, 3.04)
Model 4	1.21 (−1.31, 3.73)	1.17 (−0.90, 3.24)
P-interaction for race (Model 2)	P=0.32	P=0.55
Incident infarcts (≥3 mm)	OR (95% CI)	OR (95% CI)
Model 1	1.53 (1.01, 2.31)	1.52 (1.05, 2.19)
Model 2	1.50 (0.97, 2.30)	1.42 (0.97, 2.06)
Model 3	1.45 (0.90, 2.35)	1.30 (0.86, 1.98)
Model 4	1.61 (0.95, 2.72)	1.37 (0.88, 2.13)
P-interaction for race (Model 2)	P=0.06	P=0.52

Model 1 (demographic variables): age, sex, race

Model 2 (demographic + behavioral and socioeconomic variables): Model 1 + education, body mass index, smoking status, alcohol drinking, physical activity

Model 3 (demographic + behavioral and socioeconomic + comorbidities): Model 2 + systolic and diastolic blood pressure, use of hypertension medication, diabetes, HDL cholesterol, total cholesterol, cholesterol lowering medications, and estimated glomerular filtration rate

Model 4: (demographic + behavioral and socioeconomic + comorbidities + mediators): Model 3 + 25(OH)D, calcium, phosphorus