Table VI.
Network and Pathway analysis of the list of candidate genes identified in Tables II–IV using GATHER and GENEMANIA (Unadjusted P < 0.001).
| Annotation Type | Annotation | P-value |
|---|---|---|
| GATHER Gene Annotation and Pathway Analysis | ||
| Chromosome | 2p13 (TTC31, MOGS, INO80B, LBX2, MRPL53) | < 0.0001 |
| Transcription factor binding sites | c-Ets-2 binding sites | 0.0009 |
| KEGG Pathways | path:hsa04060: Cytokine-cytokine receptor interaction | 0.0005 |
| path:hsa00920: Sulfur metabolism | 0.0007 | |
| Gene Ontology | GO:0009607 [4]: response to biotic stimulus | 0.0003 |
| GO:0006952 [5]: defense response | 0.0004 | |
| GO:0006955 [4]: immune response | 0.0004 | |
| GO:0009613 [5]: response to pest, pathogen or parasite | 0.0009 | |
| GO:0043207 [5]: response to external biotic stimulus | 0.0009 | |
| GENEMANIA Network analysis | ||
| Functions | regulation of leukocyte activation | 5.4×10−5 |
| regulation of lymphocyte activation | 6.8×10−5 | |
| regulation of cell activation | ||
| T cell activation | 0.0002 | |
| mononuclear cell proliferation | 0.0006 | |
| positive regulation of cell activation | ||
| lymphocyte proliferation | ||
| positive regulation of leukocyte activation | ||
| regulation of T cell activation | ||
| leukocyte proliferation | 0.0008 | |
| regulation of lymphocyte proliferation | ||
| regulation of mononuclear cell proliferation | ||