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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: J Stroke Cerebrovasc Dis. 2016 Feb 2;25(4):927–937. doi: 10.1016/j.jstrokecerebrovasdis.2015.12.044

Table 1.

Inclusion and exclusion criteria for the NIBS and DBS clinical trials for poststroke rehabilitation

NIBS case study DBS case study
Inclusion criteria

  1. Age 21 years or older

  2. Chronic stroke phase (>6 months to 20 years post stroke)

  3. Unilateral stroke in brain/midbrain

  4. Ability to extend fingers, thumb, wrist at 10° or above

  5. Complaint of ability to use paretic hand

  1. Age 21 years or older

  2. Diagnosis of TPS (>6 months)

  3. MRI-confirmed lesion in the thalamus or above/below the thalamus

  4. Lesion in the semioval white matter in topography consistent with TPS

  5. Complaint of intractable hemibody pain, severe allodynia, or pain-related disability

  6. Failure to respond to at least 1 antidepressant, antiseizure medication, or narcotic
Exclusion criteria

  1. Recurrent strokes

  2. Cardiac implants

  3. Metallic implant in the head

  4. Seizure disorder

  5. Medication-resistant epilepsy in first-degree relative

  6. Neuro-/psychoactive medication

  7. History of fainting spells

  8. Pregnancy

  9. Implanted pumps, stimulators, and shunts

  10. Sensorimotor system condition

  11. Mini-mental exam score lower than 18

  12. Ongoing rehabilitation for the upper limb

  13. MRI incompatibility

  14. Not interested or unable to reach

  1. Psychiatric health problems

  2. Unstable physical health

  3. Neurological lesions beyond TPS lesion

  4. Pregnancy or inadequate contraception

  5. Certain serious comorbidities

  6. Unable to provide informed consent

Abbreviations: DBS, deep brain stimulation; MRI, magnetic resonance imaging; NIBS, noninvasive brain stimulation; TPS, thalamic pain syndrome.