Table 2.

Risk stratification tools for use in patients with NSTEMI

	PREDICT [17]	TIMI [27]	PURSUIT [28]	FRISC II [29]	GRACE [18]	SYNERGY [30]	CRUSADE [19]
Relevant population	MI or UA	UA or NSTEMI	UA or NSTEMI	UA or NSTEMI	Any ACS	NSTEMI or UA	NSTEMI aged ≥65 years
Outcome	Death	Death, MI or urgent revascularization	Death or nonfatal MI	Death or death/MI	Death or death/MI	Death	Mortality
Time horizon	30 days, 2 years, 6 years	14 days	30 days	1 year	6 months	From 30 days to 1 year	1 year
Data source	Observational cohort study	RCT	RCT	RCT	Registry	RCT	Registry
Items included	Age	Age	Age	Age	Age	Age	Age
	History of CVDb	Having ≥3 CHD risk factorsa	Gender	Gender	HR	Creatinine clearance	Serum creatinine
	CHF at presentation Shock at presentation Kidney function ECG severity score (based on presence of Q wave, ST-segment deviation, bundle branch block) Charlson comorbidity index score	Known CHD (≥50 % stenosis) Aspirin use in past 7 days Severe angina (≥2 episodes in 24 h) ECG changes of ≥0.5 mm Positive biomarker	Worst CCS class in previous 6 weeks HR SBP Signs of heart failure ST depression on presenting ECG	Diabetes Previous MI ST depression on admission Elevated biomarkers	SBP Serum creatinine Killip class Cardiac arrest at admission ST-segment deviation Elevated cardiac enzymes/markers	Weight Baseline hemoglobin level Baseline platelet count Nadir platelet count Atrial fibrillation/flutter Statin use in first 30 days since initial hospitalization CABG during first 30 days after initial hospitalization Gender	SBP Signs of heart failure on presentation HR Weight Prior heart failure Hematocrit Troponin ratio Prior stroke Diabetes Gender Prior PAD

TIMI risk score for UA/NSTEMI: http://www.mdcalc.com/timi-risk-score-for-uanstemi/

GRACE risk score for ACS: http://www.mdcalc.com/grace-acs-risk-and-mortality-calculator/

ACS acute coronary syndrome, CABG coronary artery bypass grafting, CCS Canadian Cardiovascular Society (angina measure), CHD coronary heart disease, CHF congestive heart failure, CVD cardiovascular disease, DM diabetes mellitus, ECG electrocardiogram, HR heart rate, MI myocardial infarction, NSTEMI non-ST-segment elevation myocardial infarction, PAD peripheral arterial disease, RCT randomized controlled trial, SBP systolic blood pressure, UA unstable angina

^aFamily history of CHD, hypertension, hypercholesterolemia, diabetes, or current smoker

^bHistory of MI, stroke, angina >8 weeks before admission, CABG, cardiac arrest and/or hypertension