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. 2015 May 11;7(1):79–89. doi: 10.1002/jcsm.12036

Figure 1.

Figure 1

Administration of d‐Trp(8)‐γMSH (γMSH; 500 µg/kg bw. i.p. twice daily) to arthritic rats increased body weight gain (P < 0.05, A) and gastrocnemius weight (P < 0.01, B), whereas it did not modify food intake (C). Hypothalamic interleukin‐1β and cyclooxygenase‐2 expression (D) was increased in arthritic rats (P < 0.01), whereas administration of d‐Trp(8)‐γMSH to arthritic rats decreased interleukin‐1β but not cyclooxygenase‐2 expression in the hypothalamus. Arthritis increased serum concentration of corticosterone (P < 0.01) and d‐Trp(8)‐γMSH treatment prevented the increase in serum corticosterone (E). Serum concentration of insulin‐like growth factor‐I was decreased by arthritis (P < 0.01), and d‐Trp(8)‐γMSH administration increased serum insulin‐like growth factor‐I levels, P < 0.01 (F). C, control rats; AA, arthritic rats; PF, pair‐fed rats. Data represent means ± standard error of the mean (n = 7–10). Values without the same letter are significantly different. Least significant difference multiple comparison test.