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. 2015 May 11;7(1):79–89. doi: 10.1002/jcsm.12036

Figure 4.

Figure 4

Effect of arthritis and d‐Trp(8)‐γMSH treatment (γMSH; 500 µg/kg bw. i.p. twice daily) on gastrocnemius muscle ring‐finger protein 1 mRNA (A), atrogin‐1 mRNA (B), muscle ring‐finger protein 1 protein (C) and atrogin‐1 protein (D). d‐Trp(8)‐γMSH administration decreased arthritis‐induced increase in muscle ring‐finger protein 1 and atrogin‐1 mRNA, as well as atrogin‐1 protein (P < 0.01). Arthritis increased muscle ring‐finger protein 1 protein in rats treated with saline (P < 0.05) but not in those treated with d‐Trp(8)‐γMSH. C, control rats; AA, arthritic rats; PF, pair‐fed rats. Data represent means ± standard error of the mean (n = 7–9). Values without the same letter are significantly different. Least significant difference multiple comparison test.