Table 5.
Linkage disequilibrium analysis and age calculation for the c.6046C>T mutation
| Marker (allele) | Physical position (Mb) | Distance from c.6046C>T | LD | Estimated age | ||
|---|---|---|---|---|---|---|
| Mb | θ a | δ b | gc | Yearsd | ||
| DXS7423 (189) | 149.71 | 4.42 | 0.0442 | 0.704 | – | – |
| DXS1073 (128) | 153.82 | 0.31 | 0.0031 | 0.850 | 128.00 | 3200 |
| STR24 (190) | 154.07 | 0.06 | 0.0006 | 0.500 | – | – |
| STR22 (206) | 154.10 | 0.03 | 0.0003 | 0.758 | – | – |
| c.6046C>T | 154.13 | – | – | – | – | – |
| STR13 (156) | 154.16 | 0.03 | 0.0003 | 0.833 | – | – |
| DXS1108 (171) | 154.86 | 154.86 | 1.5486 | 0.940 | 55.51 | 1387 |
a
Assuming Mb~cM.
b
Calculated according to the method of Bengtsson and Thomson: δ = (pD − pN)/(1 − pN).
c
ĝ = logδ/log(1 − θ); Luria–Delbrück correction g = −(1/r)ln(θfr), assuming r = 0.03 and fr = 1/r.
d
Assuming generations lasting 25 years.