Figure 1.

MicroRNAs and functional annotation categories in patients with multiple sclerosis (MS). MicroRNAs from the peripheral blood mononuclear cells (PBMCs) of patients with MS in the remitting stage and controls (ctrl) were subjected to microRNA array. (a) The heatmap of the microRNA array showed average values of 42 microRNAs that were significantly changed, with more than twofold differences between the groups. (b) The heatmap of microRNA array showed the same 42 dysregulated microRNAs as a cluster in four patients with MS and controls. (c) Predicted and experimentally supported targets were analysed using the Ingenuity Pathway Analysis (ipa) program for enrichment of genes into functional annotation categories. Significantly enriched categories are shown according to the significance index (SI) using the Fisher's exact test.