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. 2016 Feb 17;147(4):488–498. doi: 10.1111/imm.12583

Figure 3.

Figure 3

Predictive T helper type 1 (Th1) –Th2 regulation by miR‐140‐5p using the Ingenuity Pathway Analysis (ipa) program. Predictive analysis of microRNA–target interaction using the ipa program for the microRNAs with significantly changed expression levels in the peripheral blood mononuclear cells (PBMCs) of patients with multiple sclerosis (MS). Arrows indicate interaction between microRNAs and their targets. The up‐regulated microRNAs are highlighted in red; the down‐regulated microRNAs are highlighted in green. miR‐140‐5p directly targeted signal transducer and activator of transcription 1 (STAT1; bold arrow) and CXCL12. miR‐140‐5p indirectly targeted GATA3 through SMAD3 or HDAC4. Let‐7e directly targeted interleukin‐10 (IL‐10) and IL‐13. STAT1 directly targeted Tbx21 (T‐bet) (bolded arrow).