Figure 7.

Expression of miR‐140‐5p is negatively correlated with production of interferon‐γ (IFN‐γ) and expression of signal transducer and activator of transcription 1 (STAT1). (a) Production of IFN‐γ in the plasma of patients with remitting MS and controls (n = 10) was detected using the Bio‐Plex assay. The scatter plots represent the concentration of each sample and the chart shows the mean, standard deviation and standard error of the mean. (b) Correlation between miR‐140‐5p, STAT1 and IFN‐γ. The transcript level of miR‐140‐5p, the density of STAT1, and the concentration of IFN‐γ from patients with MS were normalized to the controls (MS/ctrl) (n = 10 for each). Pearson correlation analysis was performed between miR‐140‐5p and STAT1, miR‐140‐5p and IFN‐γ, STAT1 and IFN‐γ. The results showed a reverse correlation between miR‐140‐5p and STAT1 (R ² = 0·936), a reverse correlation between miR‐140‐5p and IFN‐γ (R ² = 0·969), a positive correlation between STAT1 and IFN‐γ (R ² = 0·983).