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Schematic representation of the workflow of physiologically based pharmacokinetic (PBPK) model development. B/P, blood to plasma ratio; CL, clearance; Dcot, diffusion (cotyledon); Dpl, diffusion (placenta); F, bioavailability; fu, free fraction; GFR, glomerular filtration rate; ka: absorption rate constant; KpPL, placental partition coefficient, kPE, placental elimination; MW, molar mass; Phys‐chem, physicochemical; PK, pharmacokinetic
