Table 2.

Summary of individual ratios of AUC_0–t and C_max (ln‐scale) at a population level

Active substances (Strength )	N	Ratios (ln‐scale)	AUC 0–t				C max
			Mean	Min.	Max.	CV	Mean	Min.	Max.	CV
Alendronate * (10 mg)	25	R2 : R1	0.02	–1.35	0.91	0.57	–0.07	–1.58	1.29	0.60
	26	T1 : R1	–0.02	–1.67	1.29	0.72	–0.17	–1.71	0.91	0.61
	25	T2 : R2	–0.12	–1.26	1.41	0.63	–0.08	–1.43	1.46	0.60
	26	T2 : T1	–0.11	–1.73	1.46	0.77	–0.01	–1.49	1.55	0.66
Alendronate * (70 mg)	68	R2 : R1	–0.04	–2.06	1.42	0.78	–0.13	–2.65	1.17	0.89
	70	T1 : R1	–0.04	–1.78	2.77	0.92	–0.12	–1.60	2.18	0.92
	67	T2 : R2	0.03	–1.81	1.41	0.72	0.04	–1.73	1.57	0.83
	67	T2 : T1	0.01	–1.78	1.33	0.75	0.01	–1.84	1.36	0.84
Atorvastatin (40 mg)	54	R2 : R1	0.10	–0.73	0.92	0.33	–0.06	–1.32	1.42	0.65
	63	T1 : R1	–0.07	–1.05	0.42	0.28	–0.12	–1.56	2.71	0.71
	54	T2 : R2	–0.03	–0.71	0.90	0.30	0.15	–0.98	1.24	0.64
	58	T2 : T1	0.13	–0.65	1.48	0.36	0.22	–3.32	2.52	0.97
Cyclosporin (100 mg)	133	R2 : R1	0.01	–0.72	0.86	0.28	–0.02	–1.44	1.57	0.64
	137	T1 : R1	0.02	–0.51	0.76	0.24	0.00	–1.35	1.46	0.53
	133	T2 : R2	0.03	–0.55	0.61	0.24	0.05	–1.50	1.48	0.58
	134	T2 : T1	0.02	–0.86	0.77	0.27	0.03	–1.60	1.49	0.62
Ebastine (20 mg)	42	R2 : R1	–0.28	–1.98	1.91	0.99	–0.09	–1.37	1.40	0.80
	42	T1 : R1	–0.07	–1.80	1.92	0.88	–0.10	–1.40	1.50	0.70
Exemestane (25 mg)	54	R2 : R1	–0.02	–0.50	0.44	0.20	–0.02	–0.92	0.94	0.45
	56	T1 : R1	0.03	–0.37	0.45	0.18	–0.04	–0.76	1.31	0.48
	54	T2 : R2	0.05	–0.32	0.37	0.15	0.05	–0.99	0.69	0.38
	54	T2 : T1	0.00	–0.42	0.38	0.20	0.07	–0.74	0.79	0.42
Mycophenolate mofetil (250 mg)	37	R2 : R1	0.00	–0.36	0.24	0.15	0.05	–1.03	1.68	0.56
	38	T1 : R1	0.02	–0.22	0.33	0.12	0.03	–1.20	1.38	0.51
	37	T2 : R2	–0.02	–0.43	0.23	0.14	–0.01	–0.68	1.21	0.42
	37	T2 : T1	–0.03	–0.48	0.38	0.17	0.01	–0.86	0.88	0.46
Mycophenolate mofetil (500 mg)	41	R2 : R1	0.00	–1.05	0.39	0.23	0.11	–1.26	1.73	0.70
	42	T1 : R1	0.01	–0.44	0.43	0.16	0.11	–0.96	1.54	0.59
	40	T2 : R2	–0.03	–0.50	0.87	0.21	–0.09	–1.23	1.04	0.50
	40	T2 : T1	–0.04	–0.37	0.22	0.13	‐0.06	–1.12	0.75	0.46
Ropinirole (2 mg)	33	R2 : R1	–0.01	–0.40	0.29	0.17	0.04	–0.29	0.45	0.21
	31	T1 : R1	–0.06	–0.41	0.31	0.17	0.09	–0.53	0.70	0.36
	31	T2 : R2	–0.05	–0.43	0.40	0.16	0.15	–0.59	0.87	0.41
	29	T2 : T1	0.01	–0.33	0.32	0.18	0.14	–0.70	0.89	0.42

AUC_0–t, area under the drug concentration–time curve from time zero to the last sampling time point; C_max, peak plasma concentration; N, number of subjects; CV, coefficient of variation.

^*Alendronate data are given as total of unchanged active substance excreted in the urine (T_Ae) and the maximum rate of drug excretion (R_max).