Figure 4.

Paclitaxel cooperates with evofosfamide to reduce MDA‐MB‐231‐TXSA‐TGL orthotopic tumors in vivo. Mice were treated as described in Materials and Methods section and imaged weekly using the Xenogen IVIS 100 bioluminescence imaging system. (A) Representative whole body bioluminescent images of the mammary tumors of a single animal from each group and (B) the line graph, showing average tumor signal over time, expressed as mean photon counts per second during the course of the experiments are shown. Animals receiving treatment with evofosfamide and paclitaxel as single agents showed a significant delay in tumor growth. In addition, all mice receiving the combination of evofosfamide and paclitaxel showed a further delay of tumor growth when compared with each agent individually. Data shown in each case are the average bioluminescent imaging from all animals in that group: points are means ± SEM.