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. 2016 Jan 20;594(6):1727–1740. doi: 10.1113/JP271321

Figure 5. ET‐1 induces lipolysis and reduces glucose uptake in 3T3‐L1 adipocytes .

Figure 5

A, lipolysis assessed by glycerol release (% of control hypoxic cells) in culture media of 3T3‐L1 adipocytes cultivated under hypoxia (3% O2) and treated or not with ET‐1 (10 nm) and bosentan (Bos) (10 μm) for 4 or 24 h. *P < 0.05 vs. control untreated cells. # P < 0.05 vs. the corresponding ET‐1‐treated cells; two‐way ANOVA (n = 4 independent experiments). Lipolysis (B), assessed by glycerol release (% of control untreated cells) in culture media and glucose uptake (C) (% of control untreated cells) in 3T3‐L1 adipocytes and treated or not for 24 h with ET‐1 (10 nm), insulin (5 nm), BQ123, BQ788 or bosentan (10 μm each) under normoxia. *P < 0.05 vs. control untreated cells. # P < 0.05 vs. the corresponding insulin‐treated cells; one‐way ANOVA on ranks (n = 5 independent experiments).