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ET‐1 binding to its ETA receptor inhibits insulin‐induced glucose uptake and activates HSL phosphorylation on Ser660, thereby inducing diacylglycerol (DAG) lipolysis into monoacylglycerol (MAG) + fatty acid (FA). MAG conversion by monoglyceride lipase (not represented) results in glycerol and fatty acid release. Glc, glucose.
