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. 2015 Dec 20;594(6):1643–1661. doi: 10.1113/JP271309

Figure 7. Hypercapnia does not alter cAMP‐stimulated NBC activity in Calu‐3 cells .

Figure 7

A, a representative pHi experiment in which NBC activity was assessed under basal and forskolin‐stimulated conditions in 5% CO2. EIPA (3 μm) was present to inhibit the NHE. B, the effect of the cAMP agonists forskolin (5 μm) and adenosine (10 μm) on NBC‐dependent HCO3 − influx. *Significant effect of agonist stimulation (P < 0.05). Data represent mean ± SEM; n = 3 for each. C, a representative pHi experiments in which forskolin‐stimulated NBC activity was assessed in conditions of acute hypercapnia. EIPA (3 μm) was present to inhibit the NHE. E, the effect of hypercapnia on forskolin‐stimulated NBC activity. Data represent mean ± SEM; n = 7 for each.