Table 3.
Associations between mercury exposure and time domain outcomes in studies of environmental mercury exposure
| First author, Year |
Mercury exposure | Time domain outcome |
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|---|---|---|---|---|---|
| SDNN | SDANN | rMSSD | CVRR | ||
| Oka, 2003 | FMD cases vs. non-cases | Mean (SD), msec: 22 (12) vs. 33 (13), P > 0.05 |
Mean (SD), %: 2.6 (1.1) vs. 3.3 (1.1), P > 0.05 |
||
| Grandjean, 2004 | Per doubling of Hg: Cord blood Cord blood Hair at 7 y Hair at 7 y Hair at 14 y |
% change in outcome: −1.27 at 7 y, P = 0.36 −2.73 at 14 y, P= 0.035 −0.344 at 7 y, P = 0.76 −1.12 at 14 y, P = 0.30 −1.52 at 14 y, P = 0.11 |
|||
| Valera, 2008 | Per 1 log-unit of blood Hg (mmol/L) increase |
β coefficient, log(msec): −0.056 (95% CI −0.12 to 0.01) |
β coefficient, log(msec): −0.086 (95% CI −0.16 to −0.01) |
β coefficient, log(msec): −0.03 (95% CI −0.09 to 0.04) |
β coefficient, log(msec): −0.057 (95% CI −0.11 to 0.001) |
| Choi, 2009 | Per 1 SD of log Hg exposure increase: Blood Toenail Hair 7 years before Latent Hg estimate |
% change in outcome: 43.3 (95% CI 20.3 to 66.3) 25.5 (95% CI −0.60 to 51.5) 25.9 (95% CI −1.39 to 53.1) 5.80 (95% CI −29.1 to 40.5) |
|||
| Lim, 2010 | Per 1 log-unit of hair (μg/g) increase |
β coefficient, log(msec): −0.032, P > 0.05 |
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| Yaginuma-Sakurai, 2010 | Experimental vs. control group at 15 wk |
Mean (SD), %: 4.47 (2.16) vs. 4.12 (1.55) |
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| Valera, 2011a | Per 1 unit of Hg increase: Blood (nmol/L) Hair (nmol/g) |
β coefficient, msec: 0.08, P = 0.93 −1.18, P = 0.22 |
β coefficient, msec: −0.61, P = 0.47 −1.28, P = 0.12 |
β coefficient, msec: −0.01, P = 0.65 −0.03, P = 0.07 |
|
| Valera, 2011b | Tertiles of blood Hg (T1, T2, T3) |
Adjusted mean (SEM), msec: Teenagers: 89 (1.1), 92 (1.1), 82 (1.1), P-trend 0.44 Adults: 84 (1.1), 75 (1.1), 82 (1.1), P-trend 0.77 |
Adjusted mean (SEM), msec: Teenagers: 54 (1.1), 57 (1.1), 52 (1.1), P-trend 0.77 Adults: 56 (1.1), 49 (1.1), 54 (1.1), P-trend 0.68 |
Adjusted mean (SEM), msec: Teenagers: 37 (1.1), 43 (1.1), 30 (1.1), P-trend 0.11 Adults: 31 (1.1), 27 (1.1), 30 (1.1), P-trend 0.66 |
|
| Valera, 2012 | Per 1 unit increase in log Hg: Cord blood (nmol/L) Blood (nmol/L) Hair (nmol/g) |
β coefficient, msec: −0.09, P = 0.31 −0.28, P = 0.01 −0.11, P = 0.27 |
β coefficient, msec: −0.08, P = 0.35 −0.32, P = 0.003 −0.10, P = 0.33 |
β coefficient, msec: −0.06, P = 0.50 −0.15, P = 0.16 −0.10, P = 0.33 |
β coefficient, msec: −0.02, P = 0.36 −0.06, P = 0.01 −0.02, P = 0.41 |