Table 4.
Associations between mercury exposure and frequency domain outcomes in studies of environmental mercury exposure
| First author, Year |
Mercury exposure | Time domain outcome LF |
HF | LF/HF |
|---|---|---|---|---|
| Oka, 2003 | FMD cases vs. non- cases |
Mean (SD), nu: 22.3 (7.9) vs. 28.2 (14.2), P > 0.05 |
Mean (SD), nu: 27.8 (16.9) vs. 41.9 (16.7), P < 0.05 |
|
| Grandjean, 2004 | Per doubling of Hg: Cord blood Cord blood Hair at 7 y Hair at 7 y Hair at 14 y |
% change in outcome: −5.98 at 7 y, P = 0.047 −6.70 at 14 y, P= 0.038 −5.13 at 7 y, P = 0.041 −2.97 at 14 y, P = 0.27 −2.06 at 14 y, P = 0.40 |
% change in outcome: −5.16 at 7 y, P = 0.19 −6.78 at 14 y, P= 0.038 −0.179 at 7 y, P = 0.96 −4.70 at 14 y, P = 0.088 −4.61 at 14 y, P = 0.056 |
% change in outcome: −0.860 at 7 y, P = 0.79 0.112 at 14 y, P= 0.97 −4.95 at 7 y, P = 0.055 1.82 at 14 y, P = 0.45 −2.69 at 14 y, P = 0.21 |
| Murata, 2006 | Per 1 SD increase in log Hg: MeHg in cord tissue Hair |
Standardized β coefficient: 0.205, P < 0.05 0.204, P < 0.05 |
Standardized β coefficient: 0.081, P > 0.05 0.091, P > 0.05 |
|
| Valera, 2008 | Per 1 log-unit increase in blood Hg (mmol/L) |
β coefficient, log(msec2): −0.01 (95% CI −0.18 to 0.16) |
β coefficient, log(msec2): −0.01 (95% CI −0.17 to 0.15) |
β coefficient, log(LF/HF): 0.01 (95% CI −0.33 to 0.34) |
| Lim, 2010 | Per 1 log-unit of hair (μg/g) increase |
β coefficient, log(msec): −0.028, P > 0.05 |
β coefficient, log(msec): −0.117, P < 0.05 |
|
| Yaginuma-Sakurai, 2010 | Experimental vs. control group at 15 wk |
Mean (SD), %: 52.0 (9.0) vs. 46.3 (9.4) |
Mean (SD), log(LF/HF): 0.07 (0.32) vs. −0.13 (0.34) |
|
| Valera, 2011a | Per 1 unit of Hg increase: Blood (nmol/L) Hair (nmol/g) |
β coefficient, msec2: 0.21, P = 0.0002 0.34, P = <0.001 |
β coefficient, msec2: 0.15, P = 0.004 0.25, P = <0.001 |
β coefficient, msec2: 0.06, P = 0.003 0.09, P = <0.001 |
| Valera, 2011b | Tertiles of blood Hg (T1, T2, T3) |
Adjusted mean (SEM), log(nu): Teenagers: 69 (1.9), 69 (1.9), 74 (1.8), P-trend 0.08 Adults: 72 (1.9), 70 (1.9), 74 (2.0), P-trend 0.50 |
Adjusted mean (SEM), log(nu): Teenagers: 31 (1.9), 31 (1.9), 26 (1.8), P-trend 0.08 Adults: 28 (1.9), 30 (1.9), 26 (2.0), P-trend 0.50 |
Adjusted mean (SEM), log(LF/HF): Teenagers: 2.3 (1.1), 2.3 (1.1), 3.0 (1.1), P-trend 0.44 Adults: 2.8 (1.1), 2.6 (1.1), 3.2 (1.1), P-trend 0.47 |
| Valera, 2012 | Per 1 unit of log Hg increase: Cord blood (nmol/L) Blood (nmol/L) Hair (nmol/g) |
β coefficient, log(msec2): −0.09, P = 0.31 −0.24, P = 0.02 −0.14, P = 0.14 |
β coefficient, log(msec2): −0.05, P = 0.57 −0.17, P = 0.11 −0.12, P = 0.22 |
β coefficient, LF/HF: −0.04, P = 0.64 −0.04, P = 0.72 0.02, P = 0.82 |