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. Author manuscript; available in PMC: 2016 Mar 20.
Published in final edited form as: J Am Chem Soc. 2012 Aug 1;134(32):13259–13265. doi: 10.1021/ja212170b

Figure 2.

Figure 2

Single-molecule collagen proteolysis kinetics. (a) The cleavage rate of heterotrimeric collagen by MMP-1 increases upon application of force (red 0.25 pN, blue 10.7 pN, black 16.7 pN). (b) The rate of proteolysis by Clostridium collagenase remains essentially unaltered upon the application of force (red 0.25 pN, blue 5.2 pN, black 15pN).