Figure 4.
Analysis Results for TCGA Breast Cancer Whole-Exome Sequencing Data
p values were adjusted for multiple testing for all reported MEGS.
(A) A network constructed based on the ten significant MEGS. Thickness of the edges and sizes of the gene labels are proportional to the times in the detected MEGS.
(B) Five significant MEGS with p < 10−4.
(C) A significant MEGS with five genes.
(D) Illustration showing MEGS pattern including protein products (colored blue) of AKT1, TP53, ARID1A, MED23, and TBL1XR1 in their relevant biological pathways. Connections including activation and interaction as well as effects on gene expression and biological processes are indicated. Components in the NCoR/SMRT and SWI/SNF complexes and the potential interaction of MED23 with p53 via the overall mediator complex are not illustrated. Connections including activation (lines with arrow) and inhibition (bar-headed lines) as well as end biological effects between the gene products are illustrated. Abbreviations are as follows: RTK, receptor tyrosine kinases; GFR, growth factor receptor.