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. 2016 Mar 21;10:51. doi: 10.3389/fnbeh.2016.00051

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Copyright © 2016 Poon, Barson, Ho and Leibowitz.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of high-fat diet on chemokine and neuropeptide expression. Ingestion of a HFD for 5 days: (A) increased the expression of endogenous CXCL12 and its receptors, CXCR4 and CXCR7, in the hypothalamic paraventricular nucleus (PVN), as well as expression of the orexigenic neuropeptides, encephalin (ENK) and galanin (GAL); (B) increased the expression of CXCL12 and its receptors in the perifornical lateral hypothalamus (PFLH), as well as expression of the orexigenic neuropeptides, orexin (OX) and melanin-concentrating hormone (MCH); and (C) had no effect on CXCL12, CXCR4, or CXCR7 mRNA levels in the arcuate nucleus (ARC), where it reduced expression of the orexigenic, neuropeptide Y (NPY). N = 16, ^†p < 0.05, ^∗p < 0.01, ^‡p < 0.001.