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. 2016 Mar 21;10:51. doi: 10.3389/fnbeh.2016.00051

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Copyright © 2016 Poon, Barson, Ho and Leibowitz.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of high-fat diet on protein levels of CXCL12 and CXCR4. (A) Ingestion of a HFD for 5 days significantly increased the levels of CXCL12 in both the PVN and PFLH, as compared to rats ingesting low-fat chow diet. N = 16. (B) Ingestion of a HFD for 5 days significantly increased the number of CXCR4-immunoreactive cells in the PVN, as compared to low-fat chow diet. (C) Representative photomicrograph of CXCR4-immunoreactive cells as illustrated in PVN from chow rats; and (D) HFD rats. N = 16, ^†p < 0.05, ^∗p < 0.01.