Figure 5.

After applying the cyclic stretch for 1 h, α-SMA protein expression was increased with TZD treatment in MM (A). The number below each lane indicates the quantified fold change with normalized to static condition without TZD and its individual β-actin. The mechanical stretch also inhibited the TZD-induced PPRE promoter activity (B). The decreased PPARγ protein expression can be reversed by adding the protease inhibitor MG-132 during the cyclic stretch (C). *Significant difference compared with GM without drugs (p < 0.05).