Figure 2. Regional GM volume differences among the three SORL1 rs3824968 genotypic groups.

T-score map shows significant smaller GM volume in SORL1 A allele carriers compared with those carrying TT (A). The clusters were set at a voxel threshold with P of <0.005 as well as extended voxel sizes of 298, all of the clusters remained significant and survived from the criteria of corrected P_alpha of <0.05 by Monte Carlo simulation. Bottom bar graph shows the GM volume difference between the SORL1 genotypes and the regions with significant gene main effect in the left middle occipital gyrus (B), right cerebellum tonsil (C), left medial frontal gyrus (D), right posterior cingulate gyrus (E), and left superior temporal gyrus (F). ^*Bonferroni-corrected P < 0.05 (post hoc tests in analysis of covariance).