Table 2. Regional GM volume differences among the three SORL1 rs3824968 genotypic groups.
| MNI Coordinates |
Voxel size | Brain region | Regional GM Volume Mean (SE) (cm3) |
F-Value | ||||
|---|---|---|---|---|---|---|---|---|
| x | y | z | AA- Homozygotes | AT- Heterozygotes | TT- Homozygotes | |||
| −33 | −79 | 22 | 378 | Left Middle Occipital Gyrus (BA 19) | 0.677 (0.008) | 0.703 (0.007) | 0.748 (0.013) | 11.52 |
| 30 | −46 | −51 | 746 | Right Cerebellum Tonsil | 1.305 (0.017) | 1.406 (0.017) | 1.344 (0.031) | 9.62 |
| −2 | −9 | 51 | 341 | Left Medial Frontal Gyrus (BA 6) | 0.572 (0.006) | 0.607 (0.006) | 0.600 (0.011) | 9.03 |
| 3 | −34 | 37 | 427 | Right Posterior Cingulate Gyrus (BA 31) | 0.941 (0.009) | 0.988 (0.009) | 0.992 (0.016) | 8.72 |
| −42 | −9 | −15 | 302 | Left Superior Temporal Gyrus (BA 48) | 0.423 (0.003) | 0.421 (0.003) | 0.446 (0.005) | 6.90 |
Z-scores are for the peak statistical significant voxel of each regional cluster with corrected Palpha of <0.05 (corrected for multiple comparisons by using Monte Carlo simulation) after controlling for age, sex, and education level. Abbreviations: BA, Brodmann area; GM, grey matter; MNI, Montreal Neurological Institute; SE, standard error.