Figure 4.

The members of the inhibitor of NF-κB (IκB) family. IκB proteins contain ankyrin repeat domains (ARDs) and signal response domains (SRDs) and are degraded in response to different signals (BCR, B-cell receptor; TCR, T-cell receptor; LPS, lipopolysaccharide; LT-β, lymphotoxin-β; BAFF, B-cell-activating factor; RANKL, receptor activator of NF-κB ligand). The ARDs on p105 and p100 (which are proteolytically processed to p50 and p52 NF-κB monomers, respectively) can act to self-inhibit p50 and p52. p100 can also form a multimeric complex in which it can inhibit other latent NF-κB dimers. Adapted from O’Dea and Hoffmann (43).