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. 2016 Feb;57(1):51–57. doi: 10.3325/cmj.2016.57.51

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Copyright © 2016 by the Croatian Medical Journal. All rights reserved.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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The effect of hyperbaric oxygen preconditioning (HBOP) on tight junction proteins (TJP) in the blood-brain barrier (BBB) in vitro under hypoxic condition. TJPs expression was tested by immunofluorescence in the control, hypoxia, and HBOP group. Distribution and expression of occludin (A) and zonula occludens protein (ZO-1) (B). Occludin (red) and ZO-1 (red) were labeled with secondary antibody against anti-occludin antibody and against anti-ZO-1 antibody. The nucleus (blue) was labeled with 4′,6-diamidino-2-phenylindole (DAPI). Images represent three independent experiments. (C) Relative mean optical density of occludin and ZO-1 immunofluorescence. Data are presented as mean ± standard deviation (n = 3, each group). **P = 0.001 vs control group; ^##P = 0.008 vs hypoxia group.