Table 3.
Cox-regression analysis for the risk of developing chronic graft vs host disease (cGvHD) depending on pulmonary function parameters at day +180 and day +365. The adjusted model included acute GvHD and reduced intensity vs myeloablative conditioning as covariates*
| Day +180 |
Day +365 |
|||||
|---|---|---|---|---|---|---|
| Parameter | N | adjusted HR (95% CI) | P | N | adjusted HR (95% CI) | P |
| LFS grade |
||||||
| I |
33 |
referent |
28 |
referent |
||
| II |
70 |
0.779 (0.457-1.330) |
0.360 |
69 |
0.970 (0.546-1.721) |
0.916 |
| III |
19 |
0.788 (0.370-1.677) |
0.536 |
13 |
3.313 (1.547-7.095) |
0.002 |
| IV |
0 |
1 |
3.540 (0.451-27.804) |
0.229 |
||
| trend |
0.640 |
trend |
0.002 |
|||
| FEV1 |
||||||
| >80% |
103 |
referent |
91 |
referent |
||
| 70%-80% |
15 |
0.852 (0.407-1.784) |
0.671 |
15 |
1.418 (0.719-2.796) |
0.313 |
| 60%-70% |
6 |
1.419 (0.432-4.661) |
0.564 |
7 |
3.029 (1.170-7.844) |
0.022 |
| 50%-60% |
1 |
27.423 (2.783-270.184) |
0.005 |
0 |
||
| 40%-50% |
1 |
0 (0-8.66x10^213) |
0.970 |
3 |
2.605 (0.775-8.761) |
0.122 |
| <40% |
0 |
0 |
||||
| trend |
0.069 |
trend |
0.054 |
|||
| cDLCO |
||||||
| >80% |
34 |
referent |
30 |
referent |
||
| 70%-80% |
24 |
0.701 (0.349-1.407) |
0.317 |
29 |
0.885 (0.453-1.728) |
0.720 |
| 60%-70% |
34 |
0.742 (0.406-1.356) |
0.333 |
30 |
0.963 (0.497-1.867) |
0.911 |
| 50%-60% |
20 |
0.545 (0.249-1.194) |
0.129 |
17 |
1.568 (0.722-3.403) |
0.256 |
| 40%-50% |
8 |
1.346 (0.507-3.576) |
0.551 |
4 |
2.867 (0.952-8.629) |
0.061 |
| <40% |
2 |
1.604 (0.373-6.901) |
0.525 |
1 |
3.000 (0.382-23.581) |
0.296 |
| trend | 0.439 | trend | 0.241 | |||
*HR – hazard ratio; LFS – lung function score; FEV1 – forced expiratory volume in the first second; cDLCO –.diffusion capacity of the lung for carbon monoxide corrected for hemoglobin level.